To date, there is no report on safety of Artemisia Kopetdaghensis. This study aimed to determine the possible undesirable effects\nof A. Kopetdaghensis on reproduction of female rats. The pregnant rats were treated (i.p.) with vehicle or 200 and 400mg/kg of A.\nKopetdaghensis hydroalcoholic extract from the 2nd to 8th day of pregnancy. Then, number and weight of neonates, duration of\npregnancy, and percent of dead fetuses were determined. Also, cytotoxicity of this plant was tested using fibroblast (L929) and ovary\n(Cho) cell lines. The A. Kopetdaghensis had no significant effect on duration of pregnancy, average number of neonates, and weight\nof neonates. However, administration of 200 and 400mg/kg of the extract led to 30 and 44% abortion in animals, respectively. The extract at c ??g/mL significantly (?? < 0.001) inhibited the proliferation of L929 fibroblast cells. Regarding\nthe Cho cells, the extract induced toxicity only at concentration of 800 ??g/mL (?? < 0.01). Our results showed that continuous\nconsumption of A. Kopetdaghensis in pregnancy may increase the risk of abortion and also may have toxic effect on some cells.
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